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However the predominanceof air?ow obstruction primarily at low lung vol-umes indicates the pathology is more likely toinvolve the small peripheral rather than largercentral airways (Lum et al. Avantaggiati ML, Ogryzko V, Gardner K, Giordano A, Levine AS, Kelly K (1997) Recruitmentof p300/CBP in p53-dependent signal pathways

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