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2006) and thus even de? n-ing what is actually “new” may be dif?cult (Reistma and Moreno 2002 ).Furthermore, in some cases where overall complications are low, in order todetermine whether an approach is better than a preexisting one, thousands ofpatients would need to be enrolled in a randomized trial (Morreim et al. There isintimal proliferation, vessel wall inflammation, and endothelial damage with release of cytokinesand endothelin-I, the later cause vasoconstriction

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